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It is included in the PEPPUDEX because it intersects with the NAD+/SAM/methionine-cycle longevity research that the wider peptide community follows

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The ability to form sedentary communities or biofilms in anatomical sites, such as the middle ear, has also been shown to contribute to the in vivo persistence of NTHi (Garca-Cobos et al., 2014)

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however, benchmarking studies reveal substantial heterogeneity among ORA tools in terms of biological informativeness and result specificity (de Oliveira et al., 2026)